A pneumonia outbreak associated with a new coronavirus of probable bat origin.
Identifieur interne : 000664 ( new/Analysis ); précédent : 000663; suivant : 000665A pneumonia outbreak associated with a new coronavirus of probable bat origin.
Auteurs : Peng Zhou [République populaire de Chine] ; Xing-Lou Yang [République populaire de Chine] ; Xian-Guang Wang [République populaire de Chine] ; Ben Hu [République populaire de Chine] ; Lei Zhang [République populaire de Chine] ; Wei Zhang [République populaire de Chine] ; Hao-Rui Si [République populaire de Chine] ; Yan Zhu [République populaire de Chine] ; Bei Li [République populaire de Chine] ; Chao-Lin Huang [République populaire de Chine] ; Hui-Dong Chen [République populaire de Chine] ; Jing Chen [République populaire de Chine] ; Yun Luo [République populaire de Chine] ; Hua Guo [République populaire de Chine] ; Ren-Di Jiang [République populaire de Chine] ; Mei-Qin Liu [République populaire de Chine] ; Ying Chen [République populaire de Chine] ; Xu-Rui Shen [République populaire de Chine] ; Xi Wang [République populaire de Chine] ; Xiao-Shuang Zheng [République populaire de Chine] ; Kai Zhao [République populaire de Chine] ; Quan-Jiao Chen [République populaire de Chine] ; Fei Deng [République populaire de Chine] ; Lin-Lin Liu [République populaire de Chine] ; Bing Yan [République populaire de Chine] ; Fa-Xian Zhan [République populaire de Chine] ; Yan-Yi Wang [République populaire de Chine] ; Geng-Fu Xiao [République populaire de Chine] ; Zheng-Li Shi [République populaire de Chine]Source :
- Nature [ 1476-4687 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Cellules Vero, Chine (épidémiologie), Chiroptera (virologie), Femelle, Flambées de maladies, Génome viral (génétique), Humains, Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Lignée cellulaire, Mâle, Peptidyl-Dipeptidase A (métabolisme), Phylogénie, Pneumopathie virale (virologie), Pneumopathie virale (épidémiologie), Similitude de séquences d'acides nucléiques, Syndrome respiratoire aigu sévère, Virus du SRAS (), Virus du SRAS (génétique).
- MESH :
- génétique : Génome viral, Virus du SRAS.
- métabolisme : Peptidyl-Dipeptidase A.
- sang : Anticorps antiviraux.
- virologie : Chiroptera, Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Chine, Infections à coronavirus, Pneumopathie virale.
- Animaux, Cellules Vero, Femelle, Flambées de maladies, Humains, Lignée cellulaire, Mâle, Phylogénie, Similitude de séquences d'acides nucléiques, Syndrome respiratoire aigu sévère, Virus du SRAS.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Betacoronavirus (classification), Betacoronavirus (genetics), Betacoronavirus (metabolism), Betacoronavirus (ultrastructure), Cell Line, China (epidemiology), Chiroptera (virology), Chlorocebus aethiops, Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Disease Outbreaks, Female, Genome, Viral (genetics), Humans, Male, Peptidyl-Dipeptidase A (metabolism), Phylogeny, Pneumonia, Viral (epidemiology), Pneumonia, Viral (virology), SARS Virus (classification), SARS Virus (genetics), Sequence Homology, Nucleic Acid, Severe Acute Respiratory Syndrome, Vero Cells.
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : China.
- classification : Betacoronavirus, SARS Virus.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus, Genome, Viral, SARS Virus.
- metabolism : Betacoronavirus, Peptidyl-Dipeptidase A.
- ultrastructure : Betacoronavirus.
- virology : Chiroptera, Coronavirus Infections, Pneumonia, Viral.
- Animals, Cell Line, Chlorocebus aethiops, Disease Outbreaks, Female, Humans, Male, Phylogeny, Sequence Homology, Nucleic Acid, Severe Acute Respiratory Syndrome, Vero Cells.
Abstract
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.
DOI: 10.1038/s41586-020-2012-7
PubMed: 32015507
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 000949
- to stream Ncbi, to step Curation: 000949
- to stream Ncbi, to step Checkpoint: 000949
- to stream Main, to step Merge: 000C63
- to stream Main, to step Curation: 000C61
- to stream Main, to step Exploration: 000C61
- to stream new, to step Extraction: 000664
Links to Exploration step
pubmed:32015507Le document en format XML
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wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Liu, Lin Lin" sort="Liu, Lin Lin" uniqKey="Liu L" first="Lin-Lin" last="Liu">Lin-Lin Liu</name><affiliation wicri:level="3"><nlm:affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Provincial Center for Disease Control and Prevention, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Yan, Bing" sort="Yan, Bing" uniqKey="Yan B" first="Bing" last="Yan">Bing Yan</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhan, Fa Xian" sort="Zhan, Fa Xian" uniqKey="Zhan F" first="Fa-Xian" last="Zhan">Fa-Xian Zhan</name><affiliation wicri:level="3"><nlm:affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Provincial Center for Disease Control and Prevention, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, Yan Yi" sort="Wang, Yan Yi" uniqKey="Wang Y" first="Yan-Yi" last="Wang">Yan-Yi Wang</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xiao, Geng Fu" sort="Xiao, Geng Fu" uniqKey="Xiao G" first="Geng-Fu" last="Xiao">Geng-Fu Xiao</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32015507</idno><idno type="pmid">32015507</idno><idno type="doi">10.1038/s41586-020-2012-7</idno><idno type="wicri:Area/PubMed/Corpus">000C07</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C07</idno><idno type="wicri:Area/PubMed/Curation">000C07</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C07</idno><idno type="wicri:Area/PubMed/Checkpoint">000B89</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B89</idno><idno type="wicri:Area/Ncbi/Merge">000949</idno><idno type="wicri:Area/Ncbi/Curation">000949</idno><idno type="wicri:Area/Ncbi/Checkpoint">000949</idno><idno type="wicri:Area/Main/Merge">000C63</idno><idno type="wicri:Area/Main/Curation">000C61</idno><idno type="wicri:Area/Main/Exploration">000C61</idno><idno type="wicri:Area/new/Extraction">000664</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A pneumonia outbreak associated with a new coronavirus of probable bat origin.</title><author><name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Yang, Xing Lou" sort="Yang, Xing Lou" uniqKey="Yang X" first="Xing-Lou" last="Yang">Xing-Lou Yang</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, Xian Guang" sort="Wang, Xian Guang" uniqKey="Wang X" first="Xian-Guang" last="Wang">Xian-Guang Wang</name><affiliation wicri:level="3"><nlm:affiliation>Wuhan Jin Yin-Tan Hospital, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Jin Yin-Tan Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Si, Hao Rui" sort="Si, Hao Rui" uniqKey="Si H" first="Hao-Rui" last="Si">Hao-Rui Si</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhu, Yan" sort="Zhu, Yan" uniqKey="Zhu Y" first="Yan" last="Zhu">Yan Zhu</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Li, Bei" sort="Li, Bei" uniqKey="Li B" first="Bei" last="Li">Bei Li</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Huang, Chao Lin" sort="Huang, Chao Lin" uniqKey="Huang C" first="Chao-Lin" last="Huang">Chao-Lin Huang</name><affiliation wicri:level="3"><nlm:affiliation>Wuhan Jin Yin-Tan Hospital, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Jin Yin-Tan Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Hui Dong" sort="Chen, Hui Dong" uniqKey="Chen H" first="Hui-Dong" last="Chen">Hui-Dong Chen</name><affiliation wicri:level="3"><nlm:affiliation>Wuhan Jin Yin-Tan Hospital, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan Jin Yin-Tan Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Jing" sort="Chen, Jing" uniqKey="Chen J" first="Jing" last="Chen">Jing Chen</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Luo, Yun" sort="Luo, Yun" uniqKey="Luo Y" first="Yun" last="Luo">Yun Luo</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Jiang, Ren Di" sort="Jiang, Ren Di" uniqKey="Jiang R" first="Ren-Di" last="Jiang">Ren-Di Jiang</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Liu, Mei Qin" sort="Liu, Mei Qin" uniqKey="Liu M" first="Mei-Qin" last="Liu">Mei-Qin Liu</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Ying" sort="Chen, Ying" uniqKey="Chen Y" first="Ying" last="Chen">Ying Chen</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Shen, Xu Rui" sort="Shen, Xu Rui" uniqKey="Shen X" first="Xu-Rui" last="Shen">Xu-Rui Shen</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, Xi" sort="Wang, Xi" uniqKey="Wang X" first="Xi" last="Wang">Xi Wang</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zheng, Xiao Shuang" sort="Zheng, Xiao Shuang" uniqKey="Zheng X" first="Xiao-Shuang" last="Zheng">Xiao-Shuang Zheng</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhao, Kai" sort="Zhao, Kai" uniqKey="Zhao K" first="Kai" last="Zhao">Kai Zhao</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Chen, Quan Jiao" sort="Chen, Quan Jiao" uniqKey="Chen Q" first="Quan-Jiao" last="Chen">Quan-Jiao Chen</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Deng, Fei" sort="Deng, Fei" uniqKey="Deng F" first="Fei" last="Deng">Fei Deng</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Liu, Lin Lin" sort="Liu, Lin Lin" uniqKey="Liu L" first="Lin-Lin" last="Liu">Lin-Lin Liu</name><affiliation wicri:level="3"><nlm:affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Provincial Center for Disease Control and Prevention, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Yan, Bing" sort="Yan, Bing" uniqKey="Yan B" first="Bing" last="Yan">Bing Yan</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhan, Fa Xian" sort="Zhan, Fa Xian" uniqKey="Zhan F" first="Fa-Xian" last="Zhan">Fa-Xian Zhan</name><affiliation wicri:level="3"><nlm:affiliation>Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hubei Provincial Center for Disease Control and Prevention, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Wang, Yan Yi" sort="Wang, Yan Yi" uniqKey="Wang Y" first="Yan-Yi" last="Wang">Yan-Yi Wang</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Xiao, Geng Fu" sort="Xiao, Geng Fu" uniqKey="Xiao G" first="Geng-Fu" last="Xiao">Geng-Fu Xiao</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation wicri:level="3"><nlm:affiliation>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Nature</title><idno type="eISSN">1476-4687</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Betacoronavirus (classification)</term><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (metabolism)</term><term>Betacoronavirus (ultrastructure)</term><term>Cell Line</term><term>China (epidemiology)</term><term>Chiroptera (virology)</term><term>Chlorocebus aethiops</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (virology)</term><term>Disease Outbreaks</term><term>Female</term><term>Genome, Viral (genetics)</term><term>Humans</term><term>Male</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Phylogeny</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (virology)</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>Sequence Homology, Nucleic Acid</term><term>Severe Acute Respiratory Syndrome</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Cellules Vero</term><term>Chine (épidémiologie)</term><term>Chiroptera (virologie)</term><term>Femelle</term><term>Flambées de maladies</term><term>Génome viral (génétique)</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Lignée cellulaire</term><term>Mâle</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Phylogénie</term><term>Pneumopathie virale (virologie)</term><term>Pneumopathie virale (épidémiologie)</term><term>Similitude de séquences d'acides nucléiques</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Betacoronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term><term>Genome, Viral</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Génome viral</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Betacoronavirus</term><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Phylogeny</term><term>Sequence Homology, Nucleic Acid</term><term>Severe Acute Respiratory Syndrome</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Lignée cellulaire</term><term>Mâle</term><term>Phylogénie</term><term>Similitude de séquences d'acides nucléiques</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats<sup>1-4</sup>. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans<sup>5-7</sup>. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name></region><name sortKey="Chen, Hui Dong" sort="Chen, Hui Dong" uniqKey="Chen H" first="Hui-Dong" last="Chen">Hui-Dong Chen</name><name sortKey="Chen, Jing" sort="Chen, Jing" uniqKey="Chen J" first="Jing" last="Chen">Jing Chen</name><name sortKey="Chen, Quan Jiao" sort="Chen, Quan Jiao" uniqKey="Chen Q" first="Quan-Jiao" last="Chen">Quan-Jiao Chen</name><name sortKey="Chen, Ying" sort="Chen, Ying" uniqKey="Chen Y" first="Ying" last="Chen">Ying Chen</name><name sortKey="Deng, Fei" sort="Deng, Fei" uniqKey="Deng F" first="Fei" last="Deng">Fei Deng</name><name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name><name sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name><name sortKey="Huang, Chao Lin" sort="Huang, Chao Lin" uniqKey="Huang C" first="Chao-Lin" last="Huang">Chao-Lin Huang</name><name sortKey="Jiang, Ren Di" sort="Jiang, Ren Di" uniqKey="Jiang R" first="Ren-Di" last="Jiang">Ren-Di Jiang</name><name sortKey="Li, Bei" sort="Li, Bei" uniqKey="Li B" first="Bei" last="Li">Bei Li</name><name sortKey="Liu, Lin Lin" sort="Liu, Lin Lin" uniqKey="Liu L" first="Lin-Lin" last="Liu">Lin-Lin Liu</name><name sortKey="Liu, Mei Qin" sort="Liu, Mei Qin" uniqKey="Liu M" first="Mei-Qin" last="Liu">Mei-Qin Liu</name><name sortKey="Luo, Yun" sort="Luo, Yun" uniqKey="Luo Y" first="Yun" last="Luo">Yun Luo</name><name sortKey="Shen, Xu Rui" sort="Shen, Xu Rui" uniqKey="Shen X" first="Xu-Rui" last="Shen">Xu-Rui Shen</name><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><name sortKey="Si, Hao Rui" sort="Si, Hao Rui" uniqKey="Si H" first="Hao-Rui" last="Si">Hao-Rui Si</name><name sortKey="Wang, Xi" sort="Wang, Xi" uniqKey="Wang X" first="Xi" last="Wang">Xi Wang</name><name sortKey="Wang, Xian Guang" sort="Wang, Xian Guang" uniqKey="Wang X" first="Xian-Guang" last="Wang">Xian-Guang Wang</name><name sortKey="Wang, Yan Yi" sort="Wang, Yan Yi" uniqKey="Wang Y" first="Yan-Yi" last="Wang">Yan-Yi Wang</name><name sortKey="Xiao, Geng Fu" sort="Xiao, Geng Fu" uniqKey="Xiao G" first="Geng-Fu" last="Xiao">Geng-Fu Xiao</name><name sortKey="Yan, Bing" sort="Yan, Bing" uniqKey="Yan B" first="Bing" last="Yan">Bing Yan</name><name sortKey="Yang, Xing Lou" sort="Yang, Xing Lou" uniqKey="Yang X" first="Xing-Lou" last="Yang">Xing-Lou Yang</name><name sortKey="Zhan, Fa Xian" sort="Zhan, Fa Xian" uniqKey="Zhan F" first="Fa-Xian" last="Zhan">Fa-Xian Zhan</name><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><name sortKey="Zhao, Kai" sort="Zhao, Kai" uniqKey="Zhao K" first="Kai" last="Zhao">Kai Zhao</name><name sortKey="Zheng, Xiao Shuang" sort="Zheng, Xiao Shuang" uniqKey="Zheng X" first="Xiao-Shuang" last="Zheng">Xiao-Shuang Zheng</name><name sortKey="Zhu, Yan" sort="Zhu, Yan" uniqKey="Zhu Y" first="Yan" last="Zhu">Yan Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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